RegulonDB RegulonDB 11.2: Gene Form
   

nlpA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

nlpA yicL yicS yicU CsgD CsgD nlpAp nlpAp TSS_4247 TSS_4247 TSS_4246 TSS_4246

Gene      
Name: nlpA    Texpresso search in the literature
Synonym(s): ECK3651, EG10657, b3661
Genome position(nucleotides): 3839175 <-- 3839993
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 47.37
External database links:  
ASAP:
 ABE-0011964
CGSC:
 35704
ECHOBASE:
 EB0651
ECOLIHUB:
 nlpA
OU-MICROARRAY:
 b3661
STRING:
 511145.b3661
COLOMBOS: nlpA


Product      
Name: lipoprotein-28
Synonym(s): NlpA
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 29.424
Isoelectric point: 6.097
Motif(s):
 
Type Positions Sequence Comment
1 -> 23 MKLTTHHLRTGAALLLAGILLAG
24 -> 272 CDQSSSDAKHIKVGVINGAEQDVAEVAKKVAKEKYGLDVELVGFSGSLLPNDATNHGELDANVFQHRPFLEQDNQAHGYKLVAVGNTFVFPMAGYSKKIKTVAQIKEGATVAIPNDPTNLGRALLLLQKEKLITLKEGKGLLPTALDITDNPRHLQIMELEGAQLPRVLDDPKVDVAIISTTYIQQTGLSPVHDSVFIEDKNSPYVNILVAREDNKNAENVKEFLQSYQSPEVAKAAETIFNGGAVPGW UniProt: Lipoprotein 28.
34 -> 272 IKVGVINGAEQDVAEVAKKVAKEKYGLDVELVGFSGSLLPNDATNHGELDANVFQHRPFLEQDNQAHGYKLVAVGNTFVFPMAGYSKKIKTVAQIKEGATVAIPNDPTNLGRALLLLQKEKLITLKEGKGLLPTALDITDNPRHLQIMELEGAQLPRVLDDPKVDVAIISTTYIQQTGLSPVHDSVFIEDKNSPYVNILVAREDNKNAENVKEFLQSYQSPEVAKAAETIFNGGAVPGW

 
Classification:
Multifun Terms (GenProtEC)  
  4 - transport
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
biological_process GO:0015821 - methionine transport
Note(s): Note(s): ...[more].
Reference(s): [1] Rao S., et al., 2020
External database links:  
ALPHAFOLD:
 P04846
ECOCYC:
 EG10657-MONOMER
ECOLIWIKI:
 b3661
INTERPRO:
 IPR004872
MODBASE:
 P04846
PANTHER:
 PTHR30429
PFAM:
 PF03180
PRIDE:
 P04846
PRODB:
 PRO_000023392
PROSITE:
 PS51257
REFSEQ:
 NP_418117
SMR:
 P04846
UNIPROT:
 P04846


Operon      
Name: nlpA         
Operon arrangement:
Transcription unit        Promoter
nlpA


Transcriptional Regulation      
Display Regulation             
Activated by: CsgD


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4246 3838644 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4247 3840008 reverse nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Rao S., Bates GT., Matthews CR., Newport TD., Vickery ON., Stansfeld PJ., 2020, Characterizing Membrane Association and Periplasmic Transfer of Bacterial Lipoproteins through Molecular Dynamics Simulations., Structure 28(4):475-487.e3

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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