RegulonDB

Gene
Name:	sbmA
Synonym(s):	ECK0372, EG10928, b0377
Genome position(nucleotides):	396639 --> 397859
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	51.35
External database links:

ASAP:	ABE-0001297
CGSC:	17914
ECHOBASE:	EB0921
ECOLIHUB:	sbmA
OU-MICROARRAY:	b0377
STRING:	511145.b0377
COLOMBOS:	sbmA

Product

Name:

peptide antibiotic/peptide nucleic acid transporter

Synonym(s):

SbmA

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane

Molecular weight:

46.459

Isoelectric point:

8.697

Motif(s):

Type	Positions	Sequence	Comment
	12 -> 32	FFLSAFVWALIAVIFWQAGGG	UniProt: Helical.
	57 -> 77	FLIFYAYYIVCVGLFALFWFI	UniProt: Helical.
	80 -> 393	PHRWQYWSILGTALIIFVTWFLVEVGVAVNAWYAPFYDLIQTALSSPHKVTIEQFYREVGVFLGIALIAVVISVLNNFFVSHYVFRWRTAMNEYYMANWQQLRHIEGAAQRVQEDTMRFASTLENMGVSFINAIMTLIAFLPVLVTLSAHVPELPIIGHIPYGLVIAAIVWSLMGTGLLAVVGIKLPGLEFKNQRVEAAYRKELVYGEDDATRATPPTVRELFSAVRKNYFRLYFHYMYFNIARILYLQVDNVFGLFLLFPSIVAGTITLGLMTQITNVFGQVRGAFQYLINSWTTLVELMSIYKRLRSFEHEL
	88 -> 108	ILGTALIIFVTWFLVEVGVAV	UniProt: Helical.
	138 -> 158	VGVFLGIALIAVVISVLNNFF	UniProt: Helical.

Classification:

Multifun Terms (GenProtEC)
		5 - cell processes --> 5.6 - protection --> 5.6.4 - drug resistance/sensitivity
		6 - cell structure --> 6.1 - membrane
		4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.am - ABC superfamily, ATP binding and membrane component
Gene Ontology Terms (GO)
	cellular_component	GO:0016020 - membrane GO:0005886 - plasma membrane GO:0005887 - integral component of plasma membrane GO:0016021 - integral component of membrane
	molecular_function	GO:0015291 - secondary active transmembrane transporter activity GO:0042626 - ATPase-coupled transmembrane transporter activity GO:0005524 - ATP binding GO:0042803 - protein homodimerization activity GO:0015638 - microcin transmembrane transporter activity GO:0019534 - toxin transmembrane transporter activity GO:1904680 - peptide transmembrane transporter activity
	biological_process	GO:0046677 - response to antibiotic GO:0015031 - protein transport GO:0015833 - peptide transport GO:0042884 - microcin transport GO:0055085 - transmembrane transport GO:0042885 - microcin B17 transport GO:1901998 - toxin transport

External database links:

ALPHAFOLD:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

PFAM:

PRIDE:

PRODB:

REFSEQ:

UNIPROT:

Operon

Name:

sbmA-yaiW

Operon arrangement:

Transcription unit	Promoter
sbmA-yaiW	sbmAp

Transcriptional Regulation
	Display Regulation
Activated by:	CpxR

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	TSS_490	396323		reverse	nd	[RS-EPT-CBR]	[1]
	promoter	TSS_491	396380		forward	nd	[RS-EPT-CBR]	[1]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

Reference(s)

[1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.