RegulonDB RegulonDB 11.2: Gene Form
   

torA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

torA torC torR torD cbpM torT TorR TorR TorR TorR torCp torCp torRp torRp

Gene      
Name: torA    Texpresso search in the literature
Synonym(s): ECK0988, EG11814, b0997
Genome position(nucleotides): 1059256 --> 1061802
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 55.32
External database links:  
ASAP:
 ABE-0003372
CGSC:
 17575
ECHOBASE:
 EB1761
ECOLIHUB:
 torA
OU-MICROARRAY:
 b0997
STRING:
 511145.b0997
COLOMBOS: torA


Product      
Name: trimethylamine N-oxide reductase 1
Synonym(s): TorA
Sequence: Get amino acid sequence Fasta Format
Cellular location: periplasmic space
Molecular weight: 94.456
Isoelectric point: 6.883
Motif(s):
 
Type Positions Sequence Comment
1 -> 39 MNNNDLFQASRRRFLAQLGGLTVAGMLGPSLLTPRRATA UniProt: Tat-type signal.
40 -> 848 AQAATDAVISKEGILTGSHWGAIRATVKDGRFVAAKPFELDKYPSKMIAGLPDHVHNAARIRYPMVRVDWLRKRHLSDTSQRGDNRFVRVSWDEALDMFYEELERVQKTHGPSALLTASGWQSTGMFHNASGMLAKAIALHGNSVGTGGDYSTGAAQVILPRVVGSMEVYEQQTSWPLVLQNSKTIVLWGSDLLKNQQANWWCPDHDVYEYYAQLKAKVAAGEIEVISIDPVVTSTHEYLGREHVKHIAVNPQTDVPLQLALAHTLYSENLYDKNFLANYCVGFEQFLPYLLGEKDGQPKDAAWAEKLTGIDAETIRGLARQMAANRTQIIAGWCVQRMQHGEQWAWMIVVLAAMLGQIGLPGGGFGFGWHYNGAGTPGRKGVILSGFSGSTSIPPVHDNSDYKGYSSTIPIARFIDAILEPGKVINWNGKSVKLPPLKMCIFAGTNPFHRHQQINRIIEGLRKLETVIAIDNQWTSTCRFADIVLPATTQFERNDLDQYGNHSNRGIIAMKQVVPPQFEARNDFDIFRELCRRFNREEAFTEGLDEMGWLKRIWQEGVQQGKGRGVHLPAFDDFWNNKEYVEFDHPQMFVRHQAFREDPDLEPLGTPSGLIEIYSKTIADMNYDDCQGHPMWFEKIERSHGGPGSQKYPLHLQSVHPDFRLHSQLCESETLRQQYTVAGKEPVFINPQDASARGIRNGDVVRVFNARGQVLAGAVVSDRYAPGVARIHEGAWYDPDKGGEPGALCKYGNPNVLTIDIGTSQLAQATSAHTTLVEIEKYNGTVEQVTAFNGPVEMVAQCEYVPASQVKS UniProt: Trimethylamine-N-oxide reductase 1.
55 -> 95 TGSHWGAIRATVKDGRFVAAKPFELDKYPSKMIAGLPDHVH
99 -> 572 RIRYPMVRVDWLRKRHLSDTSQRGDNRFVRVSWDEALDMFYEELERVQKTHGPSALLTASGWQSTGMFHNASGMLAKAIALHGNSVGTGGDYSTGAAQVILPRVVGSMEVYEQQTSWPLVLQNSKTIVLWGSDLLKNQQANWWCPDHDVYEYYAQLKAKVAAGEIEVISIDPVVTSTHEYLGREHVKHIAVNPQTDVPLQLALAHTLYSENLYDKNFLANYCVGFEQFLPYLLGEKDGQPKDAAWAEKLTGIDAETIRGLARQMAANRTQIIAGWCVQRMQHGEQWAWMIVVLAAMLGQIGLPGGGFGFGWHYNGAGTPGRKGVILSGFSGSTSIPPVHDNSDYKGYSSTIPIARFIDAILEPGKVINWNGKSVKLPPLKMCIFAGTNPFHRHQQINRIIEGLRKLETVIAIDNQWTSTCRFADIVLPATTQFERNDLDQYGNHSNRGIIAMKQVVPPQFEARNDFDIFRELCR
173 -> 173 L UniProt: In Ref. 1; CAA52095..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.7 - anaerobic respiration
  1 - metabolism --> 1.4 - energy production/transport --> 1.4.2 - electron acceptors
Gene Ontology Terms (GO)  
cellular_component GO:1904852 - trimethylamine-N-oxide reductase (cytochrome c) complex
GO:0030288 - outer membrane-bounded periplasmic space
GO:0042597 - periplasmic space
molecular_function GO:0005515 - protein binding
GO:0009055 - electron transfer activity
GO:0046872 - metal ion binding
GO:0016491 - oxidoreductase activity
GO:0050626 - trimethylamine-N-oxide reductase (cytochrome c) activity
GO:0030151 - molybdenum ion binding
GO:0043546 - molybdopterin cofactor binding
biological_process GO:0009060 - aerobic respiration
GO:0009061 - anaerobic respiration
GO:0006885 - regulation of pH
GO:0019645 - anaerobic electron transport chain
Note(s): Note(s): ...[more].
Reference(s): [1] Carey JN., et al., 2019
[2] Kaufmann P., et al., 2018
[3] Ulfig A., et al., 2018
External database links:  
ALPHAFOLD:
 P33225
DIP:
 DIP-11013N
ECOCYC:
 TORA-MONOMER
ECOLIWIKI:
 b0997
INTERPRO:
 IPR006658
INTERPRO:
 IPR009010
INTERPRO:
 IPR011887
INTERPRO:
 IPR041460
INTERPRO:
 IPR006657
INTERPRO:
 IPR006656
INTERPRO:
 IPR006655
INTERPRO:
 IPR006311
INTERPRO:
 IPR041954
MINT:
 P33225
MODBASE:
 P33225
PFAM:
 PF01568
PFAM:
 PF18364
PFAM:
 PF00384
PRIDE:
 P33225
PRODB:
 PRO_000024085
PROSITE:
 PS51318
PROSITE:
 PS00490
PROSITE:
 PS00932
REFSEQ:
 NP_415517
SMR:
 P33225
UNIPROT:
 P33225


Operon      
Name: torCAD         
Operon arrangement:
Transcription unit        Promoter
torCAD


Transcriptional Regulation      
Display Regulation             
Activated by: TorR
Repressed by: NarL


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Carey JN., Goulian M., 2019, A bacterial signaling system regulates noise to enable bet hedging., Curr Genet 65(1):65-70

 [2] Kaufmann P., Duffus BR., Mitrova B., Iobbi-Nivol C., Teutloff C., Nimtz M., Jansch L., Wollenberger U., Leimkuhler S., 2018, Modulating the Molybdenum Coordination Sphere of Escherichia coli Trimethylamine N-Oxide Reductase., Biochemistry 57(7):1130-1143

 [3] Ulfig A., Freudl R., 2018, The early mature part of bacterial twin-arginine translocation (Tat) precursor proteins contributes to TatBC receptor binding., J Biol Chem 293(19):7281-7299

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