RegulonDB RegulonDB 11.2: Gene Form
   

znuA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

mepM znuA znuC znuB Zur OxyR anti-anti-terminator anti-terminator znuAp znuAp znuCp znuCp yebAp5 yebAp5 yebAp6 yebAp6 yebAp1 yebAp1 TSS_2210 TSS_2210 TSS_2209 TSS_2209

Gene      
Name: znuA    Texpresso search in the literature
Synonym(s): ECK1858, G7017, b1857, yebL, yzzP
Genome position(nucleotides): 1941651 <-- 1942583
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 49.09
External database links:  
ASAP:
 ABE-0006191
ECHOBASE:
 EB2543
ECOLIHUB:
 znuA
OU-MICROARRAY:
 b1857
STRING:
 511145.b1857
COLOMBOS: znuA


Product      
Name: Zn2+ ABC transporter periplasmic binding protein
Synonym(s): YebL, YzzP, ZnuA
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane,periplasmic space
Molecular weight: 33.777
Isoelectric point: 5.881
Motif(s):
 
Type Positions Sequence Comment
1 -> 26 MLHKKTLLFAALSAALWGGATQAADA
27 -> 166 AVVASLKPVGFIASAIADGVTETEVLLPDGASEHDYSLRPSDVKRLQNADLVVWVGPEMEAFMQKPVSKLPGAKQVTIAQLEDVKPLLMKSIHGDDDDHDHAEKSDEDHHHGDFNMHLWLSPEIARATAVAIHGKLVELM
28 -> 305 VVASLKPVGFIASAIADGVTETEVLLPDGASEHDYSLRPSDVKRLQNADLVVWVGPEMEAFMQKPVSKLPGAKQVTIAQLEDVKPLLMKSIHGDDDDHDHAEKSDEDHHHGDFNMHLWLSPEIARATAVAIHGKLVELMPQSRAKLDANLKDFEAQLASTETQVGNELAPLKGKGYFVFHDAYGYFEKQFGLTPLGHFTVNPEIQPGAQRLHEIRTQLVEQKATCVFAEPQFRPAVVESVARGTSVRMGTLDPLGTNIKLGKTSYSEFLSQLANQYAS
116 -> 138 KSIHGDDDDHDHAEKSDEDHHHG His-rich loop;
167 -> 198 PQSRAKLDANLKDFEAQLASTETQVGNELAPL

 
Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.p - ABC superfamily, periplasmic binding component
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0042597 - periplasmic space
GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
molecular_function GO:0046872 - metal ion binding
GO:0008270 - zinc ion binding
biological_process GO:0071578 - zinc ion import across plasma membrane
GO:0006811 - ion transport
GO:0007155 - cell adhesion
GO:0030001 - metal ion transport
GO:0006829 - zinc ion transport
GO:0055069 - zinc ion homeostasis
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P39172
DIP:
 DIP-12949N
ECOCYC:
 ZNUA-MONOMER
ECOLIWIKI:
 b1857
INTERPRO:
 IPR006127
INTERPRO:
 IPR035520
INTERPRO:
 IPR006128
MODBASE:
 P39172
PDB:
 2PS3
PDB:
 2PS9
PDB:
 2PRS
PDB:
 2OGW
PDB:
 2PS0
PDB:
 2OSV
PFAM:
 PF01297
PRIDE:
 P39172
PRINTS:
 PR00690
PRODB:
 PRO_000024252
REFSEQ:
 NP_416371
SMR:
 P39172
UNIPROT:
 P39172


Operon      
Name: znuA         
Operon arrangement:
Transcription unit        Promoter
znuA


Transcriptional Regulation      
Display Regulation             
Activated by: OxyR
Repressed by: Zur


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2209 1940588 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_2210 1940853 reverse nd [RS-EPT-CBR] [1]
  promoter yebAp1 1941683 reverse nd [COMP-AINF] [2]
  promoter yebAp6 1941721 reverse nd [COMP-AINF] [2]
  promoter yebAp5 1941833 reverse nd [COMP-AINF] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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