# Copies and Copyright-Notice # # RegulonDB is free for academic/noncommercial use # # User is not entitled to change or erase data sets of the RegulonDB # database or to eliminate copyright notices from RegulonDB. Furthermore, # User is not entitled to expand RegulonDB or to integrate RegulonDB partly # or as a whole into other databank systems, without prior written consent # from CCG-UNAM. # # Please check the license at http://regulondb.ccg.unam.mx/menu/download/full_version/terms_and_conditions.jsp # # Citation # # Tierrafría, V. H. et al. (2022). RegulonDB 11.0: Comprehensive high-throughput datasets on transcriptional regulation in Escherichia coli K-12, # Microb Genom. 2022 May;8(5). doi: 10.1099/mgen.0.000833. PMID: 35584008. https://doi.org/10.1099/mgen.0.000833 # # # Contact # # Person: RegulonDB Team # Web Page: http://regulondb.ccg.unam.mx/menu/about_regulondb/contact_us/index.jsp # (regulondb@ccg.unam.mx) # # # Release: 11.2 Date: 05/22/2023 # Genome version: U00096.3, Refseq version: NC_000913.3; GI:556503834 # ___________________________________________________________________________ # Created: 06/12/2023 13:37:43 # Columns: # (1) Transcription Factor (TF) identifier assigned by RegulonDB # (2) TF name # (3) Gene coding for the TF # (4) Effector Name # (5) Effector Type # (6) TF Conformation # (7) TF conformation type (Active, Inactive) # (8) Interaction type (covalente, allosteric) # (9) Functional Conformation (Apo, Holo) # (10) Evidence that supports the TF- Conformation [Evidence name|Evidence type: S = Strong, W = Weak| Evidence code] # (11) PMID list # (12) confidenceLevel. Confidence level (Values: Confirmed, Strong, Weak) ECK125328145 AaeR aaeR AaeR Active ECK125286586 AccB accB AccB Active ECK120015994 AcrR acrR R6G negative AcrR-R6G Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 17644067 Strong ECK120015994 AcrR acrR AcrR Active Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 17644067 Strong ECK120015994 AcrR acrR Proflavin negative AcrR-Proflavin Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 17644067 Strong ECK120015994 AcrR acrR ethidium negative AcrR-ethidium Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 17644067 Strong ECK120012595 Ada ada Methyl positive Ada-Methylated Active Covalent Holo [EXP-IMP-SITE-MUTATION|S|Site mutation], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 16452614, 8720133 Strong ECK120012595 Ada ada Ada Active Apo [EXP-IDA|W|Inferred from direct assay] 7937881 Weak ECK120014170 AdiY adiY AdiY Active ECK120012515 AgaR agaR AgaR Active ECK125134683 AidB aidB AidB-isovaleryl-CoA Active ECK120030264 AlaS alaS AlaS Inactive Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins] 6264314 Strong ECK120030264 AlaS alaS L-alanine positive AlaS-L-alanine Active Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins] 6264314 Strong ECK120015630 AllR allR glyoxylate negative AllR-glyoxylate Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 12460564 Strong ECK120015630 AllR allR AllR Active Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 12460564 Strong ECK120015630 AllR allR allantoin positive AllR-allantoin Active Holo ECK120015636 AllS allS AllS Inactive Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 12460564 Strong ECK120015636 AllS allS allantoin positive AllS-allantoin Active Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 12460564 Strong ECK120012984 AlpA alpA AlpA Active ECK120011959 AlsR alsR AlsR Active Apo [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 10559180, 9401019 Weak ECK120011959 AlsR alsR D-allose AlsR-D-allose Inactive Allosteric Holo [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 10559180, 9401019 Weak ECK120012987 AppY appY AppY Active ECK120012316 AraC araC D-fucose negative AraC-D-fucose Inactive Allosteric Holo ECK120012316 AraC araC AraC Active Apo [EXP-IDA|W|Inferred from direct assay], [EXP-IMP-SITE-MUTATION|S|Site mutation], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins] 1560456, 2962192, 3041410, 7768852, 8516313, 9600836 Strong ECK120012316 AraC araC α-L-arabinopyranose positive AraC-α-L-arabinopyranose Active Allosteric Holo [EXP-IDA|W|Inferred from direct assay], [EXP-IMP-SITE-MUTATION|S|Site mutation], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins] 1560456, 2962192, 3041410, 7768852, 8516313, 9600836 Strong ECK120011345 ArcA arcA ArcA Inactive Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 10851007, 1512197, 15522865, 9286997 Strong ECK120011345 ArcA arcA Phosphate positive ArcA-phosphorylated Active Covalent Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 10851007, 1512197, 15522865, 9286997 Strong ECK120011202 ArgP argP L-lysine negative ArgP-L-lysine Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 17504942, 18502871 Strong ECK120011202 ArgP argP ArgP Active Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins] 18502871 Strong ECK120011202 ArgP argP L-arginine positive ArgP-L-arginine Active Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 17504942 Strong ECK120011670 ArgR argR ArgR Inactive Apo [EXP-IDA|W|Inferred from direct assay], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 11580241, 17074904, 3116542 Strong ECK120011670 ArgR argR L-arginine positive ArgR-L-arginine Active Allosteric Holo [EXP-IDA|W|Inferred from direct assay], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 11580241, 17074904, 3116542 Strong ECK120030724 ArsR arsR arsenite negative ArsR-arsenite Inactive Allosteric Holo ECK120030724 ArsR arsR antimonite negative ArsR-antimonite Inactive Allosteric Holo ECK120030724 ArsR arsR ArsR Active Apo ECK120026318 AscG ascG AscG Active ECK120013010 AsnC asnC AsnC Active Apo [EXP-IPI|W|Inferred from physical interaction] 16528101 Weak ECK120013010 AsnC asnC L-asparagine negative AsnC-L-asparagine Inactive Allosteric Holo [EXP-IPI|W|Inferred from physical interaction] 16528101 Weak ECK120013014 AtoC atoC AtoC Inactive Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 16153782 Strong ECK120013014 AtoC atoC Phosphate positive AtoC-phosphorylated Active Covalent Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 16153782 Strong ECK120015687 BaeR baeR BaeR Inactive Apo ECK120015687 BaeR baeR Phosphate positive BaeR-phosphorylated Active Covalent Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 15522865 Strong ECK125145855 BasR basR BasR Inactive Apo ECK125145855 BasR basR Phosphate positive BasR-phosphorylated Active Holo ECK120013017 BetI betI BetI Active Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 8626295 Strong ECK120013017 BetI betI choline negative BetI-choline Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 8626295 Strong ECK120012646 BirA birA biotinyl-5'-adenylate positive BirA-biotinyl-5'-adenylate Active Allosteric Holo ECK120012646 BirA birA BirA Inactive Apo ECK120051438 BluR bluR BluR Active ECK120029348 BolA bolA Phosphate positive BolA-phosphorylated Active ECK125145850 BtsR btsR BtsR Inactive Apo ECK125145850 BtsR btsR Phosphate positive BtsR-Phosphorylated Active Holo ECK120011235 CRP crp cyclic-AMP positive CRP-cyclic-AMP Active Allosteric Holo ECK120011235 CRP crp CRP Inactive Apo ECK125286587 CRP-Sxy crp, sxy CRP-Sxy Active ECK120011250 CadC cadC CadC Active ECK120013805 CaiF caiF L-carnitine CaiF-L-carnitine Active Holo ECK120013805 CaiF caiF CaiF Inactive Apo ECK120013750 Cbl cbl Thiosulphate negative Cbl-Thiosulphate Inactive Allosteric Holo ECK120013750 Cbl cbl adenosine 5'-phosphosulfate negative Cbl-adenosine 5'-phosphosulfate Inactive Allosteric Holo [EXP-IDA|W|Inferred from direct assay], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 11918818 Strong ECK120013750 Cbl cbl Cbl Active Apo [EXP-IDA|W|Inferred from direct assay], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 11918818 Strong ECK120011953 CdaR cdaR CdaR Active ECK125230705 CecR cecR CecR Active ECK120012036 ChbR chbR 6-phospho-β-D-glucosaminyl-(1->4)--acetyl-D-glucosamine ChbR-6-phospho-β-D-glucosaminyl-(1->4)--acetyl-D-glucosamine Active Allosteric Holo ECK120012036 ChbR chbR ChbR Active Apo ECK125141239 ComR comR ComR Active Apo ECK125141239 ComR comR Cu ComR-Cu Inactive Holo ECK120011210 CpxR cpxR Phosphate positive CpxR-phosphorylated Active Covalent Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 15522865, 16861804, 9159398 Strong ECK120011210 CpxR cpxR CpxR Inactive Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 15522865, 16861804, 9159398 Strong ECK120013112 Cra cra Cra-beta;-D-fructose 1,6-bisphosphate Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 8230205, 8577250 Strong ECK120013112 Cra cra β-D-fructofuranose 1-phosphate negative Cra-β-D-fructofuranose 1-phosphate Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 8230205, 8577250 Strong ECK120013112 Cra cra Cra Active Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 8230205, 8577250 Strong ECK120035002 CreB creB CreB Inactive Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 15522865 Strong ECK120035002 CreB creB Phosphate positive CreB-phosphorylated Active Covalent Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 15522865 Strong ECK120013342 CsgD csgD CsgD Active ECK120013061 CspA cspA CspA Active ECK125285349 CsqR csqR 6-sulfo-D-quinovose CsqR-6-sulfo-D-quinovose Inactive Holo ECK125285349 CsqR csqR CsqR Active Apo ECK125288994 CueR cueR Ag positive CueR-Ag Active Allosteric Holo ECK125288994 CueR cueR Au positive CueR-Au Active Allosteric Holo ECK125288994 CueR cueR Cu CueR-Cu Active Apo ECK120011941 CusR cusR CusR Inactive Apo [EXP-IDA|W|Inferred from direct assay], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 15522865, 15773991 Strong ECK120011941 CusR cusR Phosphate positive CusR-phosphorylated Active Covalent Holo [EXP-IDA|W|Inferred from direct assay], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 15522865, 15773991 Strong ECK120013065 CynR cynR cyanate positive CynR-cyanate Active Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 7961413 Strong ECK120013065 CynR cynR CynR Active Apo ECK120011312 CysB cysB Thiosulphate negative CysB-Thiosulfate Inactive Allosteric Holo ECK120011312 CysB cysB -acetyl-L-serine positive CysB--acetyl-L-serine Active Allosteric Holo ECK120011312 CysB cysB Sulphide negative CysB-Sulphide Inactive Allosteric Holo ECK120011312 CysB cysB N-acetyl-L-serine positive CysB-N-acetyl-L-serine Active Allosteric Holo [EXP-IMP-SITE-MUTATION|S|Site mutation], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 11038360 Strong ECK120011312 CysB cysB CysB Active ECK120012407 CytR cytR cytidine negative CytR-cytidine Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins] 1655726 Strong ECK120012407 CytR cytR CytR Active Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins] 1655726 Strong ECK120051451 Dan ttdR Dan Inactive Apo ECK120051451 Dan ttdR L-tartrate Dan-L-tartrate Active Holo ECK125286588 DcuR dcuR DcuR Inactive Apo ECK125286588 DcuR dcuR Phosphate positive DcuR-phosphorylated Active Covalent Holo ECK125235978 DecR decR DecR Active ECK120012664 DeoR deoR DeoR Active Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 2653814 Strong ECK120012664 DeoR deoR Deoxyribose-5-phosphate negative DeoR-Deoxyribose-5-phosphate Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 2653814 Strong ECK125285348 DgoR dgoR DgoR Active ECK125285348 DgoR dgoR D-galactonate DgoR-D-galactonate Inactive Holo ECK120015690 DhaR dhaR DhaR Active Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 15616579 Strong ECK120015690 DhaR dhaR DhaK negative DhaR-DhaK Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 15616579 Strong ECK120029345 DicA dicA DicA Active ECK125257188 DinJ-YafQ dinJ, yafQ DinJ-YafQ Active ECK120011903 DnaA dnaA DnaA Inactive Apo ECK120011903 DnaA dnaA ATP positive DnaA-ATP Active Allosteric Holo ECK120034476 DpiA dpiA DpiA Inactive Apo [EXP-IMP-SITE-MUTATION|S|Site mutation], [EXP-IEP|W|Inferred from expression pattern] 9701802 Strong ECK120034476 DpiA dpiA Phosphate positive DpiA-phosphorylated Active Covalent Holo [EXP-IMP-SITE-MUTATION|S|Site mutation], [EXP-IEP|W|Inferred from expression pattern] 9701802 Strong ECK120013081 DsdC dsdC DsdC Inactive Apo [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 6296057 Weak ECK120013081 DsdC dsdC D-serine positive DsdC-D-serine Active Allosteric Holo [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 6296057 Weak ECK120013085 EbgR ebgR EbgR Active ECK120035026 EnvR envR EnvR Active ECK120011792 EnvY envY EnvY Active ECK120011575 EvgA evgA EvgA Inactive Apo [EXP-IMP-SITE-MUTATION|S|Site mutation], [COMP-AINF-FN-FROM-SEQ|W|Automated inference of function from sequence], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins] 10923791 Strong ECK120011575 EvgA evgA Phosphate positive EvgA-phosphorylated Active Covalent Holo [EXP-IMP-SITE-MUTATION|S|Site mutation], [COMP-AINF-FN-FROM-SEQ|W|Automated inference of function from sequence], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins] 10923791 Strong ECK120012141 ExuR exuR α-D-glucuronate ExuR-α-D-glucuronate Inactive ECK120012141 ExuR exuR ExuR Active ECK120012141 ExuR exuR α-D-galacturonate ExuR-α-D-galacturonate, α-D-glucuronate Active ECK120011229 FNR fnr FNR Active ECK120011229 FNR fnr [2Fe-2S] oxidized negative FNR-[2Fe-2S] oxidized Inactive Covalent Apo ECK120011229 FNR fnr [4Fe-4S] reduced positive FNR-[4Fe-4S] reduced Active Covalent Holo ECK120011354 FabR fabR FabR Active ECK120011824 FadR fadR an acyl-CoA negative FadR-an acyl-CoA Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 1569108 Strong ECK120011824 FadR fadR FadR Active Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 1569108 Strong ECK120026337 FeaR feaR FeaR Active ECK120011394 FhlA fhlA formate positive FhlA-formate Active Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 10848985 Strong ECK120011394 FhlA fhlA FhlA Inactive Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 10848985 Strong ECK120011186 Fis fis Fis Active ECK125257194 FlhDC flhC, flhD FlhDC Active ECK125141939 FliZ fliZ FliZ Active ECK125302601 FrlR frlR FrlR Active ECK125302601 FrlR frlR -phospho-D-fructos-1-yl)-L-lysine FrlR--phospho-D-fructos-1-yl)-L-lysine Inactive ECK125257185 FrmR frmR formaldehyde FrmR-formaldehyde Inactive Holo ECK125257185 FrmR frmR FrmR Active Apo ECK120013118 FucR fucR FucR Inactive Apo [EXP-IMP|W|Inferred from mutant phenotype], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 3005235 Weak ECK120013118 FucR fucR L-fuculose 1-phosphate positive FucR-L-fuculose-1-P Active Allosteric Holo [EXP-IMP|W|Inferred from mutant phenotype], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 3005235 Weak ECK125285350 Fur fur Fe negative Fur-Fe Active Allosteric Holo ECK125285350 Fur fur Fur Inactive Apo ECK125285350 Fur fur Mn Fur-Mn Active Allosteric Holo ECK120012092 GadE gadE GadE Active ECK125257204 GadE-RcsB gadE, rcsB GadE-RcsB Active ECK120011465 GadW gadW GadW Active ECK120011458 GadX gadX GadX Active ECK120012713 GalR galR GalR Active Apo [EXP-IDA|W|Inferred from direct assay], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 8416900, 8982002 Strong ECK120012713 GalR galR D-galactose GalR-D-galactose Active Allosteric Holo ECK120012704 GalS galS GalS Active Apo [EXP-IDA|W|Inferred from direct assay], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 8416900, 8982002 Strong ECK120012704 GalS galS D-galactose GalS-D-galactose Active Allosteric Holo ECK120013131 GatR gatR GatR Active ECK120012465 GcvA gcvA Purine negative GcvA-Purine Inactive Allosteric Holo ECK120012465 GcvA gcvA glycine negative GcvA-glycine Inactive Allosteric Holo ECK120012465 GcvA gcvA GcvA Active Apo ECK120012075 GlaR glaR GlaR Active Apo ECK120012075 GlaR glaR glutarate GlaR-glutarate Inactive Holo ECK120011437 GlcC glcC glycolate positive GlcC-glycolate Active Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 9880556 Strong ECK120011437 GlcC glcC GlcC Inactive Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 9880556 Strong ECK120011437 GlcC glcC Acetate positive GlcC-Acetate Active Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 9880556 Strong ECK120012730 GlpR glpR -glycerol 3-phosphate negative GlpR--glycerol 3-phosphate Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 3316209 Strong ECK120012730 GlpR glpR GlpR Active Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 3316209 Strong ECK120012730 GlpR glpR glycerol GlpR-glycerol Inactive Holo ECK125108627 GlrR glrR Phosphate positive GlrR-phosphorylated Active Covalent Holo [EXP-IDA|W|Inferred from direct assay], [EXP-IEP|W|Inferred from expression pattern], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 19843219 Strong ECK125108627 GlrR glrR GlrR Inactive Apo [EXP-IDA|W|Inferred from direct assay], [EXP-IEP|W|Inferred from expression pattern], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 19843219 Strong ECK120012096 GntR gntR GntR Active Apo [EXP-IEP|W|Inferred from expression pattern], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 9135111 Weak ECK120012096 GntR gntR D-gluconate negative GntR-D-gluconate Inactive Allosteric Holo [EXP-IEP|W|Inferred from expression pattern], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 9135111 Weak ECK120013141 GutM gutM GutM Active ECK120011294 H-NS hns H-NS Active ECK125257184 HU hupA, hupB HU Active ECK120015243 HcaR hcaR HcaR Active Apo ECK120015243 HcaR hcaR 3-phenylpropanoate HcaR-3-phenylpropanoate Active Holo ECK120012250 HdfR hdfR HdfR Active ECK125286590 HicB hicB HicB Active ECK125242732 HigA higA HigA Active ECK125257189 HigB-HigA higA, higB HigB-HigA Active ECK125257201 HipAB hipA, hipB HipAB Active ECK120026325 HipB hipB HipB Active ECK125228798 HprR hprR Phosphate positive HprR-phosphorylated Active Holo ECK125228798 HprR hprR HprR Inactive Apo ECK120011390 HyfR hyfR HyfR Active ECK125141903 HypT hypT Met-oxidized HypT-Met-oxidized Active ECK125257183 IHF ihfA, ihfB IHF Active ECK120011897 IclR iclR glyoxylate negative IclR-glyoxylate Inactive Allosteric Holo ECK120011897 IclR iclR pyruvate negative IclR-pyruvate Active Allosteric Holo ECK120011897 IclR iclR IclR Inactive Apo ECK120012101 IdnR idnR Idonate positive IdnR-Idonate Active Allosteric Holo [EXP-IMP|W|Inferred from mutant phenotype], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 14973046 Weak ECK120012101 IdnR idnR 5-dehydro-D-gluconate positive IdnR-5-dehydro-D-gluconate Active Allosteric Holo [EXP-IMP|W|Inferred from mutant phenotype], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 14973046 Weak ECK120012101 IdnR idnR IdnR Inactive Apo [EXP-IMP|W|Inferred from mutant phenotype], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 14973046 Weak ECK120012965 IlvY ilvY ()-2-acetolactate positive IlvY-()-2-acetolactate Active Allosteric Holo [EXP-IDA|W|Inferred from direct assay], [EXP-IMP-SITE-MUTATION|S|Site mutation], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 9556617 Strong ECK120012965 IlvY ilvY IlvY Active Apo [EXP-IDA|W|Inferred from direct assay], [EXP-IMP-SITE-MUTATION|S|Site mutation], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 9556617 Strong ECK120012965 IlvY ilvY Alfa-acetohydroxybutirate positive IlvY-Alfa-acetohydroxybutirate Active Allosteric Holo [EXP-IDA|W|Inferred from direct assay], [EXP-IMP-SITE-MUTATION|S|Site mutation], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 9556617 Strong ECK120011429 IscR iscR a [2Fe-2S] iron-sulfur cluster positive IscR-a [2Fe-2S] iron-sulfur cluster Active Covalent Holo [EXP-IDA|W|Inferred from direct assay], [EXP-IEP|W|Inferred from expression pattern], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 11742080, 19361432 Strong ECK120011429 IscR iscR IscR Active Apo [EXP-IEP|W|Inferred from expression pattern], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 19361432 Strong ECK120015250 KdgR kdgR KdgR Active ECK125286591 KdpE kdpE KdpE Inactive Apo ECK125286591 KdpE kdpE Phosphate positive KdpE-phosphorylated Active Covalent Holo ECK120012762 LacI lacI allolactose negative LacI-allolactose Inactive Allosteric Holo ECK120012762 LacI lacI LacI Active Apo ECK120013164 LeuO leuO LeuO Active ECK120012770 LexA lexA LexA Active ECK120013830 LldR lldR LldR Active Apo [EXP-IMP-SITE-MUTATION|S|Site mutation], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 18263722 Strong ECK120013830 LldR lldR ()-lactate positive LldR-()-lactate Active Allosteric Holo [EXP-IMP-SITE-MUTATION|S|Site mutation], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 18263722 Strong ECK120011328 LrhA lrhA LrhA Active ECK120011383 Lrp lrp Lrp Active Apo ECK120011383 Lrp lrp L-leucine positive Lrp-L-leucine Active Allosteric Holo ECK120015681 LsrR lsrR (2)-2-hydroxy-3,4-dioxopentyl phosphate negative LsrR-(2)-2-hydroxy-3,4-dioxopentyl phosphate Inactive Allosteric Holo ECK120015681 LsrR lsrR (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran LsrR-(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran Inactive Holo ECK120015681 LsrR lsrR LsrR Active Apo ECK120015681 LsrR lsrR autoinducer 2 negative LsrR-autoinducer 2 Inactive Allosteric Holo ECK120013175 LysR lysR LysR Active ECK120013406 MalI malI MalI Active ECK120012218 MalT malT ATP positive MalT-maltotriose-ATP Active Allosteric Holo [EXP-IDA|W|Inferred from direct assay], [EXP-IPI|W|Inferred from physical interaction] 2524384, 3298211 Weak ECK120012218 MalT malT MalY negative MalT-MalY Inactive Allosteric Holo ECK120012218 MalT malT MalK negative MalT-MalK Inactive Allosteric Holo [EXP-IMP-SITE-MUTATION|S|Site mutation], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 15733913 Strong ECK120012218 MalT malT Aes negative MalT-Aes Inactive Allosteric Holo ECK120012218 MalT malT MalT Inactive Apo [EXP-IDA|W|Inferred from direct assay] 3298211 Weak ECK120012218 MalT malT maltotriose positive MalT-maltotriose-ADP Active Allosteric Holo ECK120012218 MalT malT ADP positive MalT-maltotriose-ADP Active Allosteric Holo ECK120012218 MalT malT maltotriose positive MalT-maltotriose-ATP Active Allosteric Holo [EXP-IDA|W|Inferred from direct assay], [EXP-IPI|W|Inferred from physical interaction] 2524384, 3298211 Weak ECK120011412 MarA marA MarA Active ECK120013191 MarR marR Plumbagin negative MarR-Plumbagin Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 7768850 Strong ECK120013191 MarR marR Sodium salicylate negative MarR-Sodium salicylate Inactive Allosteric Holo ECK120013191 MarR marR Paraquat negative MarR-Paraquat Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 7768850 Strong ECK120013191 MarR marR Menadione negative MarR-Menadione Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 7768850 Strong ECK120013191 MarR marR salicylate negative MarR-salicylate Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 7768850 Strong ECK120013191 MarR marR 2,4-dinitrophenol negative MarR-2,4-dinitrophenol Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 7768850 Strong ECK120013191 MarR marR Phenazine methosulfate negative MarR-Phenazine methosulfate Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 7768850 Strong ECK120013191 MarR marR Benzoate negative MarR-Benzoate Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 7768850 Strong ECK120013191 MarR marR MarR Active Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 7768850 Strong ECK125141911 MatA matA MatA Active ECK125140737 MazE mazE MazE Active ECK125257200 MazE-MazF mazE, mazF MazE-MazF Active ECK120051441 McbR mcbR McbR Active ECK120012347 MelR melR melibiose positive MelR-melibiose Active Allosteric Holo [EXP-IDA|W|Inferred from direct assay], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 10760178, 18346968 Strong ECK120012347 MelR melR MelR Active Apo [EXP-IDA|W|Inferred from direct assay], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 10760178, 18346968 Strong ECK125302602 MetJ metJ MetJ Inactive Apo ECK125302602 MetJ metJ -adenosyl-L-methionine MetJ--adenosyl-L-methionine Active Allosteric Holo ECK125302602 MetJ metJ -methyl-5'-thioadenosine MetJ-MTA Inactive ECK125302602 MetJ metJ adenine MetJ-adenine Inactive [EXP-IPI|W|Inferred from physical interaction] 22890386 Weak ECK120012802 MetR metR MetR Active Apo [EXP-IMP-SITE-MUTATION|S|Site mutation], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 1943695, 2205852 Strong ECK120012802 MetR metR L-homocysteine positive MetR-L-homocysteine Active Allosteric Holo [EXP-IMP-SITE-MUTATION|S|Site mutation], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 1943695, 2205852 Strong ECK120011482 MhpR mhpR 3-(2,3-dihydroxyphenyl)propionate [DHPP] positive MhpR-3-(2,3-dihydroxyphenyl)propionate [DHPP] Active Allosteric Holo ECK120011482 MhpR mhpR 3-(3-hydroxyphenyl)propanoate positive MhpR-3-(3-hydroxyphenyl)propanoate Active Allosteric Holo ECK120011482 MhpR mhpR MhpR Inactive Apo ECK120011240 Mlc mlc EIIGlc negative Mlc-EIIGlC Inactive Allosteric Holo [EXP-IDA|W|Inferred from direct assay], [EXP-IEP|W|Inferred from expression pattern], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins] 11032803, 11157755 Strong ECK120011240 Mlc mlc Mlc Active Apo [EXP-IDA|W|Inferred from direct assay], [EXP-IEP|W|Inferred from expression pattern], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins] 11032803, 11157755 Strong ECK125134665 MlrA mlrA MlrA Active ECK120011949 MngR mngR MngR Active ECK125302600 MntR mntR Mn MntR-Mn Active Apo ECK125302600 MntR mntR Cd positive MntR-Cd Active Allosteric Holo ECK120011220 ModE modE ModE Inactive Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 10446207 Strong ECK120011220 ModE modE molybdate positive ModE-molybdate Active Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 10446207 Strong ECK120011593 MprA mprA 2,4-dinitrophenol negative MprA-2,4-dinitrophenol Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 10438794, 10991887, 7730261 Strong ECK120011593 MprA mprA MprA Active Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 10438794, 10991887, 7730261 Strong ECK120011593 MprA mprA Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone negative MprA-Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 10438794, 10991887, 7730261 Strong ECK120011593 MprA mprA salicylate negative MprA-salicylate Inactive ECK120011593 MprA mprA carbonylcyanide -chlorophenylhydrazone negative MprA-carbonylcyanide m-chlorophenylhydrazone Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 10438794, 10991887, 7730261 Strong ECK120051460 MqsA mqsA MqsA Active ECK125165914 MraZ mraZ MraZ Active ECK120048826 MurR murR MurR Active Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 18723630 Strong ECK120048826 MurR murR -acetyl-D-muramate 6-phosphate negative MurR--acetyl-D-muramate 6-phosphate Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 18723630 Strong ECK120011265 Nac nac Nac Active ECK120013202 NadR nadR NadR Active ECK120011908 NagC nagC NagC Active Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IMP|W|Inferred from mutant phenotype] 1766379 Strong ECK120011908 NagC nagC -acetyl-D-glucosamine 6-phosphate negative NagC--acetyl-D-glucosamine 6-phosphate Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IMP|W|Inferred from mutant phenotype] 1766379 Strong ECK120012559 NanR nanR NanR Active Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins] 15534208 Strong ECK120012559 NanR nanR -acetylneuraminate negative NanR--acetylneuraminate Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins] 15534208 Strong ECK120011502 NarL narL Phosphate positive NarL-phosphorylated Active Covalent Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 15522865 Strong ECK120011502 NarL narL NarL Inactive Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 15522865 Strong ECK120011508 NarP narP Phosphate positive NarP-phosphorylated Active Covalent Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 15522865 Strong ECK120011508 NarP narP NarP Inactive Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 15522865 Strong ECK120035042 NemR nemR methylglyoxal NemR-methylglyoxal Inactive Holo ECK120035042 NemR nemR NemR Active Apo ECK125134855 NfeR nfeR Ni negative NfeR-Ni Inactive Allosteric Holo [EXP-IDA|W|Inferred from direct assay], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 21097627 Weak ECK125134855 NfeR nfeR NfeR Active Apo ECK125134855 NfeR nfeR NfeR-Fe Inactive Allosteric Holo ECK120011378 NhaR nhaR NhaR Inactive Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 1316901, 9312050 Strong ECK120011378 NhaR nhaR Na positive NhaR-Na Active Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 1316901, 9312050 Strong ECK125302598 NikR nikR Cd positive NikR-Cd Active Allosteric Holo ECK125302598 NikR nikR Ni negative NikR-Ni Active Apo ECK125302598 NikR nikR NikR Active Allosteric Holo ECK125302598 NikR nikR Co negative NikR-Co Active Allosteric Holo ECK125302598 NikR nikR Zn positive NikR-Zn Active Allosteric Holo ECK125302598 NikR nikR Cu NikR-Cu Active Allosteric Holo ECK125228822 NimR nimR NimR Active ECK120011938 NorR norR NorR Active ECK120033053 NrdR nrdR Zn positive NrdR-Zn Active Allosteric Holo [COMP-AINF-FN-FROM-SEQ|W|Automated inference of function from sequence], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IMP|W|Inferred from mutant phenotype] 17496099 Strong ECK120033053 NrdR nrdR ATP positive NrdR-ATP Active Allosteric Holo [COMP-AINF-FN-FROM-SEQ|W|Automated inference of function from sequence], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IMP|W|Inferred from mutant phenotype] 17496099 Strong ECK120033053 NrdR nrdR NrdR Inactive Apo ECK120033053 NrdR nrdR dATP positive NrdR-dATP Active Allosteric Holo [COMP-AINF-FN-FROM-SEQ|W|Automated inference of function from sequence], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IMP|W|Inferred from mutant phenotype] 17496099 Strong ECK120016814 NsrR nsrR nitric oxide NsrR-nitric oxide Inactive Holo ECK120016814 NsrR nsrR NsrR Active Apo ECK120016814 NsrR nsrR [2Fe-2S] oxidized negative NsrR-[2Fe-2S] oxidized Inactive Covalent Apo ECK120016814 NsrR nsrR [2Fe-2S] reduced positive NsrR-[2Fe-2S]reduced Active Covalent Holo ECK125257192 NtrC glnG Phosphate positive NtrC-phosphorylated Active Covalent Holo ECK125257196 OmpR ompR Phosphate positive OmpR-phosphorylated Active Covalent Holo ECK125257196 OmpR ompR OmpR Active Apo ECK120011302 OxyR oxyR OxyR Active ECK120011563 PaaX paaX PaaX Active Apo ECK120011563 PaaX paaX phenylacetyl-CoA PaaX-phenylacetyl-CoA Inactive Holo ECK125242743 PdeL pdeL PdeL Active ECK120012246 PdhR pdhR pyruvate negative PdhR-pyruvate Inactive Allosteric Holo [EXP-IDA|W|Inferred from direct assay], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins] 17513468, 7783622 Strong ECK120012246 PdhR pdhR PdhR Active Apo [EXP-IDA|W|Inferred from direct assay], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins] 17513468, 7783622 Strong ECK120020634 PepA pepA PepA Active ECK125158270 PgrR pgrR PgrR Active ECK120011306 PhoB phoB PhoB Inactive Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 15522865 Strong ECK120011306 PhoB phoB Phosphate positive PhoB-phosphorylated Active Covalent Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 15522865 Strong ECK120011492 PhoP phoP PhoP Inactive Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 15522865 Strong ECK120011492 PhoP phoP Phosphate positive PhoP-phosphorylated Active Covalent Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 15522865 Strong ECK120014044 PlaR plaR PlaR Active ECK120015234 PrpR prpR (2)-2-methylcitrate positive PrpR-(2)-2-methylcitrate Active Allosteric Holo ECK120015234 PrpR prpR PrpR Inactive Apo ECK120011400 PspF pspF PspF Active ECK120011400 PspF pspF PspF Active ECK125328144 PunR punR PunR Active ECK120012854 PurR purR PurR Inactive Apo ECK120012854 PurR purR Guanine positive PurR-Guanine Active Allosteric Holo ECK120012854 PurR purR hypoxanthine positive PurR-hypoxanthine Active Allosteric Holo ECK120012029 PutA putA PutA Active ECK125160661 PuuR puuR putrescine PuuR-putrescine Inactive Holo ECK125160661 PuuR puuR PuuR Active Apo ECK125158264 PyrR pyrR PyrR-phosphorylated Active ECK125158264 PyrR pyrR pyruvate negative PyrR-pyruvate Active Holo ECK125158264 PyrR pyrR PyrR Inactive Apo ECK120012277 QseB qseB QseB Inactive Apo ECK120012277 QseB qseB Phosphate positive QseB-Phosphorylated Active Covalent Holo ECK125257199 RacR racR RacR Active ECK120013229 RbsR rbsR RbsR Active Apo [EXP-IDA|W|Inferred from direct assay], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 1304369 Strong ECK120013229 RbsR rbsR D-ribose negative RbsR-D-ribose Inactive Allosteric Holo [EXP-IDA|W|Inferred from direct assay], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 1304369 Strong ECK125158217 RcdA rcdA RcdA Active ECK125158217 RcdA rcdA trimethylamine -oxide RcdA-trimethylamine -oxide Inactive ECK125158217 RcdA rcdA tris RcdA-tris Inactive ECK125162247 RclR rclR RclR Active ECK120033010 RcnR rcnR Ni negative RcnR-Ni Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 16956381, 17120142 Strong ECK120033010 RcnR rcnR RcnR Active Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 16956381, 17120142 Strong ECK120033010 RcnR rcnR Co negative RcnR-Co Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 16956381, 17120142 Strong ECK125257195 RcsAB rcsA, rcsB RcsAB Active ECK120011324 RcsB rcsB RcsB Inactive Apo [EXP-IMP-SITE-MUTATION|S|Site mutation], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 9209051 Strong ECK120011324 RcsB rcsB Phosphate positive RcsB-phosphorylated Active Covalent Holo [EXP-IMP-SITE-MUTATION|S|Site mutation], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 9209051 Strong ECK120011324 RcsB rcsB acetyl RcsB-acetylated Inactive ECK125257193 RcsB-BglJ bglJ, rcsB RcsB-BglJ Active ECK120048934 RelB relB RelB Active ECK125257202 RelB-RelE relB, relE RelB-RelE Active ECK120012877 RhaR rhaR RhaR Inactive Apo ECK120012877 RhaR rhaR α-L-rhamnopyranose positive RhaR-α-L-rhamnopyranose Active Allosteric Holo ECK120012877 RhaR rhaR L-rhamnose RhaR-L-rhamnose Active Holo ECK120012337 RhaS rhaS α-L-rhamnopyranose positive RhaS-α-L-rhamnopyranose Active Allosteric Holo [EXP-IMP-SITE-MUTATION|S|Site mutation], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 18366439 Strong ECK120012337 RhaS rhaS RhaS Active Apo ECK120012337 RhaS rhaS L-rhamnose RhaS-L-rhamnose Active Holo ECK120011190 Rob rob Rob Active ECK125336166 RpoN rpoN RpoN Active ECK125158221 RspR rspR RspR Active ECK120033066 RstA rstA Phosphate positive RstA-phosphorylated Active Covalent Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 15522865 Strong ECK120033066 RstA rstA RstA Inactive Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 15522865 Strong ECK120011489 RtcR rtcR RtcR Active ECK120033905 RutR rutR uracil negative RutR-uracil Inactive Allosteric Holo [EXP-IDA|W|Inferred from direct assay], [EXP-IEP|W|Inferred from expression pattern], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins] 17919280 Strong ECK120033905 RutR rutR thymine negative RutR-thymine Inactive Allosteric Holo [EXP-IDA|W|Inferred from direct assay], [EXP-IEP|W|Inferred from expression pattern], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins] 17919280 Strong ECK120033905 RutR rutR RutR Active Apo [EXP-IDA|W|Inferred from direct assay], [EXP-IEP|W|Inferred from expression pattern], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins] 17919280 Strong ECK120011856 SdiA sdiA SdiA Active ECK120032161 SgrR sgrR SgrR Active ECK120012253 SlyA slyA SlyA Active ECK120013242 SoxR soxR [2Fe-2S] oxydized positive SoxR-[2Fe-2S] oxydized Active Covalent Holo [EXP-IDA|W|Inferred from direct assay], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 7673113 Strong ECK120013242 SoxR soxR [2Fe-2S] reduced negative SoxR-[2Fe-2S] reduced Inactive Covalent Apo [EXP-IDA|W|Inferred from direct assay], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 7673113 Strong ECK120013242 SoxR soxR SoxR Active ECK120011298 SoxS soxS SoxS Active ECK120013144 SrlR srlR SrlR Active Apo ECK120013144 SrlR srlR D-sorbitol negative SrlR-D-sorbitol Inactive Allosteric Holo [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 3062173 Weak ECK120034571 StpA stpA StpA Active ECK125202685 SutR sutR SutR Active ECK120013255 TdcA tdcA TdcA Active ECK120013259 TdcR tdcR TdcR Active ECK120012482 TorR torR Phosphate positive TorR-phosphorylated Active Covalent Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 15522865 Strong ECK120012482 TorR torR TorR Active Apo ECK120012482 TorR torR TorI negative TorR-TorI Inactive Covalent Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 15522865 Strong ECK120011406 TreR treR TreR Active Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 9148912 Strong ECK120011406 TreR treR Trehalose negative TreR-Trehalose Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 9148912 Strong ECK120011406 TreR treR TreR-α,α-trehalose 6-phosphate Inactive Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 9148912 Strong ECK120011406 TreR treR D-trehalose 6-phosphate TreR-D-trehalose 6-phosphate Inactive Allosteric Holo ECK120012176 TrpR trpR TrpR Inactive Apo ECK120012176 TrpR trpR L-tryptophan positive TrpR-L-tryptophan Active Allosteric Holo ECK120011194 TyrR tyrR L-phenylalanine positive TyrR-L-phenylalanine Active Allosteric Holo [EXP-IMP-SITE-MUTATION|S|Site mutation], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 7961453 Strong ECK120011194 TyrR tyrR L-tyrosine positive TyrR-L-tyrosine Active Allosteric Holo [EXP-IMP-SITE-MUTATION|S|Site mutation], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 7961453 Strong ECK120011194 TyrR tyrR TyrR Active Apo [EXP-IMP-SITE-MUTATION|S|Site mutation], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 7961453 Strong ECK120011194 TyrR tyrR L-tryptophan positive TyrR-L-tryptophan Active Allosteric Holo [EXP-IMP-SITE-MUTATION|S|Site mutation], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 7961453 Strong ECK125286592 UhpA uhpA UhpA Inactive Apo ECK125286592 UhpA uhpA Phosphate positive UhpA-phosphorylated Active Covalent Holo ECK120012153 UidR uidR UidR Active ECK120012165 UlaR ulaR UlaR Active Apo ECK120012165 UlaR ulaR L-ascorbate 6-phosphate UlaR-L-ascorbate 6-phosphate Inactive Holo ECK125228870 UvrY uvrY Phosphate positive UvrY-phosphorylated Active Holo ECK125228870 UvrY uvrY UvrY Inactive Apo ECK120012145 UxuR uxuR UxuR Active Apo [EXP-IMP|W|Inferred from mutant phenotype], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 6281232 Weak ECK120012145 UxuR uxuR D-fructuronate negative UxuR-D-fructuronate Inactive Allosteric Holo [EXP-IMP|W|Inferred from mutant phenotype], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 6281232 Weak ECK120012145 UxuR uxuR α-D-galacturonate UxuR-α-D-glucuronate-α-D-galacturonate Inactive Holo ECK120012145 UxuR uxuR α-D-glucuronate UxuR-α-D-glucuronate-α-D-galacturonate Inactive Holo ECK120013780 XapR xapR XapR Inactive Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 10400599, 7559336 Strong ECK120013780 XapR xapR xanthosine positive XapR-xanthosine Active Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 10400599, 7559336 Strong ECK120013786 XylR xylR α-D-xylopyranose XylR-α-D-xylopyranose Active Allosteric Holo ECK120013786 XylR xylR XylR Inactive Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IEP-GENE-EXPRESSION-ANALYSIS|W|Gene expression analysis] 7559336 Strong ECK125257198 XynR xynR D-xylonate XynR-D-xylonate Active Holo ECK125257198 XynR xynR XynR Inactive Apo ECK125336164 YciT yciT YciT Active ECK125286589 YcjW ycjW YcjW Active ECK125300414 YdcI ydcI YdcI Active ECK120012313 YdeO ydeO YdeO Active ECK125228840 YebK yebK 2-dehydro-3-deoxy-D-gluconate 6-phosphate YebK-2-dehydro-3-deoxy-D-gluconate 6-phosphate Inactive Holo ECK125228840 YebK yebK YebK Active Apo ECK125135147 YefM yefM YefM Active ECK125257203 YefM-YoeB yefM, yoeB YefM-YoeB Active ECK120013665 YeiL yeiL YeiL Active ECK125336162 YfeC yfeC YfeC Active ECK125336165 YgbI ygbI YgbI Active ECK120051444 YgiV ygiV YgiV Active ECK125257182 YhaJ yhaJ YhaJ Active ECK125336163 YidZ yidZ YidZ Active ECK125228843 YjjQ yjjQ YjjQ Active ECK125110189 YqhC yqhC YqhC Active ECK125302599 ZntR zntR Zn positive ZntR-Zn Active Allosteric Holo ECK125302599 ZntR zntR Hg positive ZntR-Hg Active Allosteric Holo ECK125302599 ZntR zntR Cd positive ZntR-Cd Active Allosteric Holo ECK125302599 ZntR zntR ZntR Inactive Apo ECK120014103 ZraR zraR Phosphate positive ZraR-phosphorylated Active Covalent Holo ECK120014103 ZraR zraR ZraR Inactive Apo ECK120012020 Zur zur Zur Inactive Apo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 10816566, 11523983 Strong ECK120012020 Zur zur Zn positive Zur-Zn Active Allosteric Holo [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS|S|Binding of purified proteins], [EXP-IPI|W|Inferred from physical interaction] 10816566, 11523983 Strong