RegulonDB RegulonDB 11.2:Regulon Page
   

ArgR DNA-binding transcriptional dual regulator

Synonyms: ArgR-L-arginine, ArgR
Summary:


Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) References
ArgR Non-Functional   Apo [EXP-IDA], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS], [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IPI] S [1], [2], [3]
ArgR-L-arginine Functional Allosteric Holo [EXP-IDA], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS], [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IPI] S [1], [2], [3]
Evolutionary Family: ArgR
TFBs length: 18
Sensing class: Sensing external and internal signals
Connectivity class: Local Regulator
Gene name: argR
  Genome position: 3384703-3385173
  Length: 471 bp / 156 aa
Operon name: argR
TU(s) encoding the TF:
Transcription unit        Promoter
argR
argRp1
argR
argRp2


Regulon       
Regulated gene(s) argA, argB, argC, argD, argE, argF, argG, argH, argI, argR, artI, artJ, artM, artP, artQ, astA, astB, astC, astD, astE, carA, carB, gltB, gltD, gltF, hisJ, hisM, hisP, hisQ, infB, lysO, metY, nusA, pnp, rbfA, rimP, rpsO, truB
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
arginine (16)
amino acids (5)
ABC superfamily, membrane component (4)
membrane (4)
other (mechanical, nutritional, oxidative stress) (4)
Read more >
Regulated operon(s) argA, argCBH, argD, argE, argF, argG, argI, argR, argT-hisJQMP, artJ, artPIQM, astCADBE, carAB, gltBDF, lysO, metY-rimP-nusA-infB-rbfA-truB-rpsO-pnp
First gene in the operon(s) argA, argC, argD, argE, argF, argG, argI, argR, artJ, artP, astC, carA, gltB, hisJ, lysO, metY
Simple and complex regulons AdiY,ArgR,CRP,FNR,Fur,GadE,HdfR,IHF,Lrp,Nac
ArgR
ArgR,CRP
ArgR,DksA-ppGpp,ppGpp
ArgR,H-NS
Read more >
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)
[ArgR,+](1)
[ArgR,-](16)


Transcription factor regulation    


Transcription factor binding sites (TFBSs) arrangements
      

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) References
  ArgR-L-arginine repressor argAp Sigma70 46.5 -40.5 argA
ctgcgaaaaaACAGAATAAAAATACACTAatttcgaata
 2949193 2949211 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS], [COMP-HINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] S [1], [4], [4], [5]
  ArgR-L-arginine repressor argAp Sigma70 67.5 -19.5 argA
atacactaatTTCGAATAATCATGCAAAgaggtgtgcc
 2949214 2949231 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [COMP-AINF-SIMILAR-TO-CONSENSUS], [COMP-HINF-SIMILAR-TO-CONSENSUS], [EXP-CHIP-EXO], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] C [1], [4], [4], [5], [6]
  ArgR-L-arginine repressor argCp Sigma70 -3.5 -119.5 argC, argB, argH
ggtcatgataGTATCAATATTCATGCAGtatttatgaa
 4154873 4154890 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-CELLULAR-EXTRACTS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS], [EXP-IMP-SITE-MUTATION] C [1], [4], [4], [5], [7]
  ArgR-L-arginine repressor argCp Sigma70 19.5 -97.5 argC, argB, argH
atgcagtattTATGAATAAAAATACACTaacgttgagc
 4154895 4154912 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [COMP-AINF-SIMILAR-TO-CONSENSUS], [EXP-CHIP-EXO], [EXP-IDA-BINDING-OF-CELLULAR-EXTRACTS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS], [EXP-IMP-SITE-MUTATION] C [1], [1], [4], [4], [5], [6], [7]
  ArgR-L-arginine repressor argDp Sigma70 -19.5 -60.5 argD
attgccatttAGTGATTTTTTATGCATAttttgtggtt
 3490232 3490249 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS], [COMP-HINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] S [1], [4], [4], [5]
  ArgR-L-arginine repressor argDp Sigma70 2.5 -39.5 argD
atgcatatttTGTGGTTATAATTTCACAtttgtttatg
 3490211 3490228 [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [COMP-AINF-SIMILAR-TO-CONSENSUS], [EXP-CHIP-EXO], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] C [1], [1], [4], [4], [5], [6]
  ArgR-L-arginine repressor argEp1 Sigma70 -6.5 -56.5 argE
gctcaacgttAGTGTATTTTTATTCATAaatactgcat
 4154895 4154912 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [COMP-AINF-SIMILAR-TO-CONSENSUS], [EXP-CHIP-EXO], [EXP-IDA-BINDING-OF-CELLULAR-EXTRACTS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS], [EXP-IMP-SITE-MUTATION] C [1], [1], [4], [4], [5], [6], [7]
  ArgR-L-arginine repressor argEp1 Sigma70 16.5 -34.5 argE
ttcataaataCTGCATGAATATTGATACtatcatgacc
 4154873 4154890 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-CELLULAR-EXTRACTS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS], [EXP-IMP-SITE-MUTATION] C [1], [4], [4], [5], [7]
  ArgR-L-arginine repressor argFp Sigma70 -22.5 -57.5 argF
tggggttgcaAATGAATAATTACACATAtaaagtgaat
 290354 290371 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-CELLULAR-EXTRACTS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] C [1], [4], [4], [5], [7], [8], [9], [10]
  ArgR-L-arginine repressor argFp Sigma70 -1.5 -36.5 argF
acacatataaAGTGAATTTTAATTCAATaagtggcgtt
 290333 290350 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [COMP-AINF-SIMILAR-TO-CONSENSUS], [EXP-CHIP-EXO], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS], [EXP-IMP-SITE-MUTATION] C [1], [4], [4], [5], [6], [7], [9], [10], [10]
  ArgR-L-arginine repressor argGp Sigma70 -125.5 -200.5 argG
ttgctaatcaTGTGAATGAATATCCAGTtcactttcat
 3318428 3318445 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS], [COMP-HINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] S [1], [4], [4], [5], [11], [11]
  ArgR-L-arginine repressor argGp Sigma70 -6.5 -81.5 argG
ataaaagatgATTAAATGAAAACTCATTtattttgcat
 3318547 3318564 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS], [COMP-HINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] S [1], [4], [4], [5], [11], [11]
  ArgR-L-arginine repressor argGp Sigma70 15.5 -60.5 argG
actcatttatTTTGCATAAAAATTCAGTgagagcggaa
 3318568 3318585 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS], [COMP-HINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] S [1], [4], [4], [5], [11], [11]
  ArgR-L-arginine repressor argIp Sigma70 -22.5 -55.5 argI
tagacttgcaAATGAATAATCATCCATAtaaattgaat
 4478358 4478375 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-CELLULAR-EXTRACTS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] C [1], [4], [4], [5], [7]
  ArgR-L-arginine repressor argIp Sigma70 -1.5 -34.5 argI
atccatataaATTGAATTTTAATTCATTgaggcgttag
 4478337 4478354 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [COMP-AINF-SIMILAR-TO-CONSENSUS], [EXP-CHIP-EXO], [EXP-IDA-BINDING-OF-CELLULAR-EXTRACTS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] C [1], [4], [4], [5], [6], [7]
  ArgR-L-arginine repressor argRp1 Sigma70 -27.5 -53.5 argR
gggctgactgTTTGCATAAAAATTCATCtgtatgcaca
 3384641 3384658 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS], [COMP-HINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] S [1], [2], [4], [4], [5], [8], [8]
  ArgR-L-arginine repressor argRp1 Sigma70 -7.5 -33.5 argR
aattcatctgTATGCACAATAATGTTGTatcaaccacc
 3384661 3384678 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [COMP-AINF-SIMILAR-TO-CONSENSUS], [COMP-HINF-SIMILAR-TO-CONSENSUS], [EXP-CHIP-EXO], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] C [1], [2], [4], [4], [5], [6], [8], [8]
  ArgR-L-arginine repressor artJp Sigma70 -48.5 -99.5 artJ
ttttatttcaTTTAAATTATTTAATCATGtttattgcat
 900666 900684 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS], [EXP-IMP-SITE-MUTATION] C [1], [6], [12], [12]
  ArgR-L-arginine repressor artJp Sigma70 -27.5 -78.5 artJ
taatcatgttTATTGCATATAAATTCACTtgatggcatt
 900645 900663 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS], [EXP-IMP-SITE-MUTATION] C [1], [5], [12], [12]
  ArgR repressor artPp Sigma70 -50.5 -85.5 artP, artI, artQ, artM
tgcgctttgcTTTTAACTTTTAAAGCAGAaatattgcat
 903811 903829 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS], [EXP-IMP-SITE-MUTATION] C [1], [6], [12], [12]
  ArgR repressor artPp Sigma70 -29.5 -64.5 artP, artI, artQ, artM
aaagcagaaaTATTGCATAATTATTCTGTcaaaggtact
 903790 903808 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS], [EXP-IMP-SITE-MUTATION] C [1], [5], [12], [12]
  ArgR-L-arginine activator astCp2 Sigma54 -121.5 -183.5 astC, astA, astD, astB, astE
attcacccacATCGCAAACGTATTCACTttatatgcac
 1832157 1832174 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [COMP-AINF-SIMILAR-TO-CONSENSUS], [EXP-CHIP-EXO], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] C [1], [6], [13], [13]
  ArgR-L-arginine activator astCp2 Sigma54 -99.5 -161.5 astC, astA, astD, astB, astE
ttcactttatATGCACTTTAAATGCATAtggtttggtt
 1832135 1832152 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] S [13], [13]
  ArgR-L-arginine activator astCp2 Sigma54 -78.5 -140.5 astC, astA, astD, astB, astE
atgcatatggTTTGGTTATAACTCCTTGatttccagtt
 1832114 1832131 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] S [13], [13]
  ArgR-L-arginine activator astCp2 Sigma54 -47.5 -109.5 astC, astA, astD, astB, astE
tccagttagcCTCCGCCGTTTATGCACTtttatcactg
 1832083 1832100 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] S [13], [13]
  ArgR-L-arginine repressor carAp2 Sigma70 -8.5 -40.5 carA, carB
acgtcatcatTGTGAATTAATATGCAAAtaaagtgagt
 29602 29619 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS], [COMP-HINF-SIMILAR-TO-CONSENSUS], [EXP-CHIP-EXO], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS], [EXP-IMP-SITE-MUTATION] C [1], [4], [4], [5], [6], [14], [14], [15]
  ArgR-L-arginine repressor carAp2 Sigma70 13.5 -19.5 carA, carB
atgcaaataaAGTGAGTGAATATTCTCTggagggtgtt
 29623 29640 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [COMP-AINF-SIMILAR-TO-CONSENSUS], [COMP-HINF-SIMILAR-TO-CONSENSUS], [EXP-CHIP-EXO], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS], [EXP-IMP-SITE-MUTATION] C [1], [4], [4], [5], [6], [14], [14], [15]
  ArgR-L-arginine repressor gltBp Sigma70 -352.0 -568.0 gltB, gltD, gltF
gcttttatcaACTGCATAATCAATCAAAattaccgaaa
 3354148 3354165 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-HINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] S [6], [6], [16], [16]
  ArgR-L-arginine repressor gltBp Sigma70 -331.5 -547.5 gltB, gltD, gltF
aatcaaaattACCGAAATTTCATGCATAatcacataaa
 3354169 3354186 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-HINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] S [6], [6], [16], [16]
  ArgR-L-arginine repressor gltBp2 Sigma38 -352.0 -568.0 gltB, gltD, gltF
gcttttatcaACTGCATAATCAATCAAAattaccgaaa
 3354148 3354165 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-HINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] S [6], [6], [16], [16]
  ArgR-L-arginine repressor gltBp2 Sigma38 -331.5 -547.5 gltB, gltD, gltF
aatcaaaattACCGAAATTTCATGCATAatcacataaa
 3354169 3354186 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-HINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] S [6], [6], [16], [16]
  ArgR-L-arginine repressor hisJp Sigma70 -83.5 -132.5 hisJ, hisQ, hisM, hisP
tggtgcattgAAATGCATACTTAAGCATTtttaatgaaa
 2426912 2426930 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS], [EXP-IMP-SITE-MUTATION] C [1], [6], [12], [12]
  ArgR-L-arginine repressor hisJp Sigma70 -62.5 -111.5 hisJ, hisQ, hisM, hisP
taagcattttTAATGAAAAATAATACGTCtaacggggcg
 2426891 2426909 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS], [EXP-IMP-SITE-MUTATION] C [1], [1], [5], [12], [12]
  ArgR-L-arginine repressor lysOp Sigma70 -55.5 -93.5 lysO
tactgctcctTATGCATAACATTTCCTTttaattgcaa
 914942 914959 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS], [EXP-IMP-SITE-MUTATION] C [1], [6], [17], [17]
  ArgR-L-arginine repressor lysOp Sigma70 -34.5 -72.5 lysO
tttccttttaATTGCAACTTTACTCGTCcttccgcttt
 914921 914938 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS], [EXP-IMP-SITE-MUTATION] C [17], [17]
  ArgR-L-arginine repressor metYp2 Sigma70 -201.5 -287.5 metY, rimP, nusA, infB, rbfA, truB, rpsO, pnp
ttccgctctcACTGAATTTTTATGCAAAataaatgagt
 3318568 3318585 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS], [COMP-HINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] S [1], [4], [5], [11], [11]
  ArgR-L-arginine repressor metYp2 Sigma70 -180.5 -266.5 metY, rimP, nusA, infB, rbfA, truB, rpsO, pnp
atgcaaaataAATGAGTTTTCATTTAATcatcttttat
 3318547 3318564 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS], [COMP-HINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] S [1], [4], [5], [11], [11]
  ArgR-L-arginine repressor metYp2 Sigma70 -61.5 -147.5 metY, rimP, nusA, infB, rbfA, truB, rpsO, pnp
atgaaagtgaACTGGATATTCATTCACAtgattagcaa
 3318428 3318445 [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-AINF-SIMILAR-TO-CONSENSUS], [COMP-HINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] S [1], [4], [5], [11], [11]



High-throughput Transcription factor binding sites (TFBSs)
      

  Functional conformation Function Object name Object type Distance to first Gene Sequence LeftPos RightPos Center Position Growth Condition Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) References
  ArgR-L-arginine activator gltP Gene nd
aatctttccaTAACAAATGGTTATTCATTAATCCTGCCATAAACTCGCGTtattatgcat
4294256 4294295 4294275.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine activator ykgA Gene nd
gaatgactgcTGTGAATCAAAATGCAAAGAGAGTGCAATATCAAGCATAGatttcgcggt
316883 316922 316902.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine activator gltP Gene nd
cctgccataaACTCGCGTTATTATGCATTAATGCAGCGAAAAGCTCTGTTgttaaagggt
4294288 4294327 4294307.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine activator yaaU Gene nd
cgtaacgccgCACTGACTCTCATTGCAAAAAACAGGAATAACCATGCAACcgtccagaaa
45774 45813 45793.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine activator puuB Gene nd
gaccgaacatACCAGCAGTTACTACGCCGCCAGTGCGAATAAATATGCACcattcgacac
1364244 1364283 1364263.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine activator eutS Gene nd
atattcgctgTGGTGCATAAACTTTCATATGCAACGCATGAATATAAATAaaataatatc
2575928 2575967 2575947.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine activator yraQ Gene nd
ctatcaattcTTGGGAATAATTATTCAGCTCTTTTGCGTAATTCTGAAGAgcttaaaatc
3298201 3298240 3298220.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine activator gltP Gene nd
taatcatctgGTGATGAAGATTATGTCATTGAGCTGCATAAAAAATAATCgaatgaacat
4294147 4294186 4294166.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine activator aroP Gene nd
tcaatatgtaGAATGAATTTAAATTCGTTTTAATTGAATTAAAAATCACAaaattggtaa
121792 121831 121811.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine activator yffB Gene nd
tttcacccttAAATGAGTATTTATTCTCATAAATCGAAAAAGGATTCATTatggttacac
2591207 2591246 2591226.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine repressor waaA Gene nd
agtttcaatgAATCGCATAAAAATACAAAAAAAATGAAGATGTAGCGGCAgatcagacca
3808394 3808433 3808413.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine repressor yhcC Transcription-Unit nd
gcttttatcaACTGCATAATCAATCAAAATTACCGAAATTTCATGCATAAtcacataaat
3354148 3354187 3354167.0 nd [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [COMP-AINF-SIMILAR-TO-CONSENSUS], [EXP-CHIP-EXO], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] C [1], [6], [18]
  ArgR-L-arginine repressor hchA Gene nd
cacgcttcccATATAGAAATATTTGCAAAAATAGTGCATGAAATAAGCTTtttctctacc
2035484 2035523 2035503.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine repressor stpA Gene nd
gacaaaatcaAAGTGAATAAAAATGCAATATAACAGAATAAAAGAAAACAtccatcactg
2798743 2798782 2798762.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine repressor cvpA Gene nd
ataaaaatggCGCTGAAAAAATATTCAACGCCATCGACTTTTTATGCCTTtgcggcatcg
2430869 2430908 2430888.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine repressor dacC Gene nd
cttgcagcggGTTCTGCATTTTTATTCCTTTTTGCCCCAACGGCATTCGCggcggaacaa
880767 880806 880786.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine repressor gltB Gene nd
gagcagcctgCTCATCATATTTATGCAGTAATTGAGATCCCCTCTTCACCgtattaaccg
3354541 3354580 3354560.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine repressor mcaS Gene nd
acgaaaatatAAGTTACATTATTAATATCGTGAATGAATAATCATGCATAagtattttgc
1405819 1405858 1405838.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine repressor pyrL Gene nd
caaacggtttATTTGAATTAAAAGTCAAGGTATATGCATTTTTATTTGATgtgattctgc
4472623 4472662 4472642.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine repressor aroK Gene nd
cgggtttggcAACTGAATAAATCACCCATCCCTCTGCATATCTGGTCGCTgcaagcgcgc
3519202 3519241 3519221.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine repressor hisL Gene nd
ggttaaaagaCATCAGTTGAATAAACATTCACAGAGACTTTTATGACACGcgttcaattt
2089964 2090003 2089983.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine repressor lrp Gene nd
gtattcttatATGCGCATAACCATGCATGTAAATACCATGTTTACCGTGCtagtgaaatc
932353 932392 932372.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine repressor ftsZ Gene nd
gttggctgcgAAAAGAGTTTTAATTTTTATGAGGCCGACGATGATTACGGcctcaggcga
105232 105271 105251.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine repressor hchA Gene nd
tctaccaatcCGGGATATAAATATTCATCAGCACCACAATATTCCACAGCactaaatctc
2035538 2035577 2035557.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine repressor dps Gene nd
aaagacggtgTAGAGGAAAAGTAGCGAGAAATTCTGCATGGTTATGCATAaccatgcaga
849151 849190 849170.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine repressor mukE Gene nd
tggcctcgacGAACTGGATAATCATGCATTCCTGATGGATTTTCAGGAATatctggaaga
975739 975778 975758.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine repressor potF Gene nd
ttacaccgcgCCGATAAAAAATATGCACGTTTATTGCATATCTTTCAGTGtgacaacttt
893697 893736 893716.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine repressor pfkB Gene nd
ttatttcattTTTTGAATAAGCATGTGGCGAAAACAGATTTTTATTTATAtatatttatc
1806222 1806261 1806241.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine repressor ydgI Gene nd
ttcagtggcaAACTCCATTTTTATGCGTTTTGCCCTAATATTTATTCTTCttatcacgtt
1679490 1679529 1679509.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
  ArgR-L-arginine repressor yfcC Gene nd
tttctgattaTCTTGCTTAACTGCGCTGCATCAATGAATTGCGCCATCCCactttgcata
2416994 2417033 2417013.0 nd [EXP-IEP-MICROARRAY], [COMP-AINF-PATTERN-DISCOVERY], [EXP-CHIP-EXO] S [1]
Other High-throughput regulatory interactions with weak evidence


Alignment and PSSM for ArgR TFBSs    

Aligned TFBS of ArgR   
  Sequence
  TATTTTGCATAAAAATTCAGT
  TTTATTGCATATAAATTCACT
  AATATTGCATAATTATTCTGT
  CTGTTTGCATAAAAATTCATC
  CTTATTGAATTAAAATTCACT
  TTATATGGATGATTATTCATT
  TTATTTGCATATTAATTCACA
  AAATATGCATAAAAAATCACT
  ATTTATGAATAAAAATACACT
  TAAATTGAATTTTAATTCATT
  TCATGTGAATGAATATCCAGT
  AATTTTGATTGATTATGCAGT
  TTATATGTGTAATTATTCATT
  GATTATGCATGAAATTTCGGT
  AAAAATGCTTAAGTATGCATT
  TAAAGTGAGTGAATATTCTCT
  AATACTGCATGAATATTGATA
  CTCTTTGCATGATTATTCGAA
  ATTAGTGTATTTTTATTCTGT
  TTTTGTGGTTATAATTTCACA
  CCTTATGCATAACATTTCCTT
  ATGATTAAATGAAAACTCATT
  TTTAATGAAAAATAATACGTC
  CTGTATGCACAATAATGTTGT
  ATTTCTGCTTTAAAAGTTAAA
  CCATATGCATTTAAAGTGCAT
  TAAAGTGAATACGTTTGCGAT
  TTAATTGCAACTTTACTCGTC
  AAACATGATTAAATAATTTAA
  TGGTTTGGTTATAACTCCTTG
  AAAAGTGCATAAACGGCGGAG

Position weight matrix (PWM). ArgR matrix-quality result    
A	11	12	13	13	11	0	1	10	23	2	17	22	17	17	25	2	2	0	17	6	6
C	6	3	1	1	2	0	0	16	0	1	1	1	1	1	1	2	3	25	2	7	3
G	1	1	4	0	6	0	30	3	2	0	8	0	2	0	1	3	4	3	6	7	2
T	13	15	13	17	12	31	0	2	6	28	5	8	11	13	4	24	22	3	6	11	20

Consensus    
;	consensus.strict             	ttattTGcaTaaaaattCatt
;	consensus.strict.rc          	AATGAATTTTTATGCAAATAA
;	consensus.IUPAC              	wwwwwTGmaTrawwattCabt
;	consensus.IUPAC.rc           	AVTGAATWWTYATKCAWWWWW
;	consensus.regexp             	[at][at][at][at][at]TG[ac]aT[ag]a[at][at]attCa[cgt]t
;	consensus.regexp.rc          	A[ACG]TGAAT[AT][AT]T[CT]AT[GT]CA[AT][AT][AT][AT][AT]

PWM logo   


 


Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
TF-target gene evolutionary conservation
Promoter-target gene evolutionary conservation


Evidence    

 [EXP-IDA] Inferred from direct assay

 [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] Binding of purified proteins

 [EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis

 [EXP-IPI] Inferred from physical interaction

 [COMP-AINF-SIMILAR-TO-CONSENSUS] Automated inference based on similarity to consensus sequences

 [COMP-HINF-SIMILAR-TO-CONSENSUS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.

 [EXP-IEP-MICROARRAY] high throughput expression microarray evidence

 [COMP-AINF-PATTERN-DISCOVERY] Automated inference based on sequence pattern discovery

 [EXP-CHIP-EXO] high throughput ChIP-exo evidence

 [EXP-IDA-BINDING-OF-CELLULAR-EXTRACTS] Binding of cellular extracts

 [EXP-IMP-SITE-MUTATION] Site mutation


Reference(s)    

 [1] Caldara M., Charlier D., Cunin R., 2006, The arginine regulon of Escherichia coli: whole-system transcriptome analysis discovers new genes and provides an integrated view of arginine regulation., Microbiology 152(Pt 11):3343-54

 [2] Lim DB., Oppenheim JD., Eckhardt T., Maas WK., 1987, Nucleotide sequence of the argR gene of Escherichia coli K-12 and isolation of its product, the arginine repressor., Proc Natl Acad Sci U S A 84(19):6697-701

 [3] Szwajkajzer D., Dai L., Fukayama JW., Abramczyk B., Fairman R., Carey J., 2001, Quantitative analysis of DNA binding by the Escherichia coli arginine repressor., J Mol Biol 312(5):949-62

 [4] Charlier D., Roovers M., Van Vliet F., Boyen A., Cunin R., Nakamura Y., Glansdorff N., Pierard A., 1992, Arginine regulon of Escherichia coli K-12. A study of repressor-operator interactions and of in vitro binding affinities versus in vivo repression., J Mol Biol 226(2):367-86

 [5] Makarova KS., Mironov AA., Gelfand MS., 2001, Conservation of the binding site for the arginine repressor in all bacterial lineages., Genome Biol 2(4):RESEARCH0013

 [6] Cho S., Cho YB., Kang TJ., Kim SC., Palsson B., Cho BK., 2015, The architecture of ArgR-DNA complexes at the genome-scale in Escherichia coli., Nucleic Acids Res 43(6):3079-88

 [7] Cunin R., Eckhardt T., Piette J., Boyen A., Pierard A., Glansdorff N., 1983, Molecular basis for modulated regulation of gene expression in the arginine regulon of Escherichia coli K-12., Nucleic Acids Res 11(15):5007-19

 [8] Levitt M., 1992, Accurate modeling of protein conformation by automatic segment matching., J Mol Biol 226(2):507-33

 [9] Tian G., Lim D., Carey J., Maas WK., 1992, Binding of the arginine repressor of Escherichia coli K12 to its operator sites., J Mol Biol 226(2):387-97

 [10] Tian G., Maas WK., 1994, Mutational analysis of the arginine repressor of Escherichia coli., Mol Microbiol 13(4):599-608

 [11] Krin E., Laurent-Winter C., Bertin PN., Danchin A., Kolb A., 2003, Transcription regulation coupling of the divergent argG and metY promoters in Escherichia coli K-12., J Bacteriol 185(10):3139-46

 [12] Caldara M., Minh PN., Bostoen S., Massant J., Charlier D., 2007, ArgR-dependent repression of arginine and histidine transport genes in Escherichia coli K-12., J Mol Biol 373(2):251-67

 [13] Kiupakis AK., Reitzer L., 2002, ArgR-independent induction and ArgR-dependent superinduction of the astCADBE operon in Escherichia coli., J Bacteriol 184(11):2940-50

 [14] Charlier D., Weyens G., Roovers M., Piette J., Bocquet C., Pierard A., Glansdorff N., 1988, Molecular interactions in the control region of the carAB operon encoding Escherichia coli carbamoylphosphate synthetase., J Mol Biol 204(4):867-77

 [15] Wang H., Glansdorff N., Charlier D., 1998, The arginine repressor of Escherichia coli K-12 makes direct contacts to minor and major groove determinants of the operators., J Mol Biol 277(4):805-24

 [16] Paul L., Mishra PK., Blumenthal RM., Matthews RG., 2007, Integration of regulatory signals through involvement of multiple global regulators: control of the Escherichia coli gltBDF operon by Lrp, IHF, Crp, and ArgR., BMC Microbiol 7:2

 [17] Pathania A., Sardesai AA., 2015, Distinct Paths for Basic Amino Acid Export in Escherichia coli: YbjE (LysO) Mediates Export of L-Lysine., J Bacteriol 197(12):2036-47

 [18] Cho BK., Federowicz S., Park YS., Zengler K., Palsson BO., 2011, Deciphering the transcriptional regulatory logic of amino acid metabolism., Nat Chem Biol 8(1):65-71


RegulonDB