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| Synonyms: CsqR, CsqR-6-sulfo-D-quinovose |
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Summary:
CsqR, formerly known as YihW and hypothesized to be a transcriptional regulator [4], functions as a repressor for genes of catabolism of sulfoquinovose (SQ), a hydrolysis product of sulfoquinovosyl diacylglycerol (SQDG) [1]. CsqR belongs to the DeoR family of transcription factors. It acts as a carbon source-dependent dual regulator involved in sustaining baseline growth in the absence of the lac operon [5]. CsqR is likely involved in regulation of lactose metabolism and functions either in a complementary or opposite manner to a global regulator of carbohydrate metabolism, cAMP-CRP, and functions as a sugar-dependent dual regulator [5]. CsqR is part of a cluster of genes involved in degradation of sulfoquinovose (SQ); see the |FRAME: PWY-7446| pathway. The activity of the CsqR transcriptional regulator is controlled by SQ and sulfoquinovosyl glycerol (SQG) during the exponential growth phase. Both SQ and SQG act as inducers for the yihUTS operon and yihV gene, and also for csqR expression [1]. It was determined by Genomic SELEX screening that CsqR binds strongly only between yihV-csqR (squV-csqR) and yihUTS (squUTS) operons, and CsqR binds with minor strength close to the trxB, yeaC, hyfB, and accC genes [3]. Read more > |
| Transcription factor |  |
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| TF conformation(s): |
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| TFBs symmetry: | inverted-repeat | |||||||||||||||||||||
| Connectivity class: | Local Regulator | |||||||||||||||||||||
| Gene name: | csqR | |||||||||||||||||||||
| Genome position: | 4074669-4075454 | |||||||||||||||||||||
| Length: | 786 bp / 261 aa | |||||||||||||||||||||
| Operon name: | yihV-csqR | |||||||||||||||||||||
| TU(s) encoding the TF: |
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| Regulon |
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| Regulated gene(s) | csqR, yihS, yihT, yihU, yihV | ||||||
| Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
carbon compounds (4)
Transcription related (1)
repressor (1)
regulon (1)
detoxification (1)
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| Regulated operon(s) | yihUTS, yihV-csqR | ||||||
| First gene in the operon(s) | yihU, yihV, csqR | ||||||
| Simple and complex regulons | CRP,CsqR CsqR | ||||||
| Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) | ||||||
| Transcription factor regulation |
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Transcription factor binding sites (TFBSs) arrangements
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| Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence | Confidence level (C: Confirmed, S: Strong, W: Weak) | References | |
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| CsqR | repressor | csqRp | Sigma70 | nd | nd | csqR | nd | nd | [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-GSELEX], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] | S | [1], [1] | ||
| CsqR | repressor | yihUp5 | Sigma70 | -11.0 | -103.0 | yihU, yihT, yihS |
caccaattgtTTAAAAAGTGACGGCTGTCAATTTTTtgacgataaa
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4073662 | 4073687 | [EXP-GSELEX], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS], [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-CHIP-EXO], [EXP-GSELEX], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] | C | [1], [1], [2], [3] | |
| CsqR | repressor | yihVp1 | Sigma70 | -38.0 | -65.0 | yihV, csqR |
tttatcgtcaAAAAATTGACAGCCGTCACTTTTTAAacaattggtg
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4073662 | 4073687 | [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-CHIP-EXO], [EXP-GSELEX], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] | C | [1], [1], [2], [3] |
| Evolutionary conservation of regulatory elements | |
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| Promoter-target gene evolutionary conservation |
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| Reference(s) |
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[EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis