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| Synonyms: MurR, MurR-N-acetyl-D-muramate 6-phosphate |
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Summary:
MurR "N-acetyl muramic acid repressor," represses genes involved in the catabolism of cell wall sugars [1]. It represses transcription from the murQ promoter and also interferes with its own transcription. murR and murQ are unique and now well-known genes that are regulated by MurR. They are divergently oriented and expressed from nonoverlapping face-to-face (convergent) promoters, and their transcripts are complementary at their 5' ends [1]. MurR is a member of the RpiR/AlsR family of transcriptional regulators, whose members contain two domains, a highly conserved N-terminal HTH domain and a C-terminal SIS (sugar phosphate isomerase/sugar phosphate-binding) domain [1, 4]. It forms a stable multimer (most likely a tetramer) and binds to two adjacent inverted repeats within the murR/murQ operator region, preventing recruitment of RNA polymerase. MurNAc-6-P is the effector of MurR. MurR carries a so-called SIS domain in its C terminal which is involved in MurNAc-6-P binding. Read more > |
| Transcription factor |  |
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| TF conformation(s): |
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| Evolutionary Family: | RpiR | |||||||||||||||||||||
| TFBs length: | 15 | |||||||||||||||||||||
| Connectivity class: | Local Regulator | |||||||||||||||||||||
| Gene name: | murR | |||||||||||||||||||||
| Genome position: | 2544752-2545609 | |||||||||||||||||||||
| Length: | 858 bp / 285 aa | |||||||||||||||||||||
| Operon name: | murR | |||||||||||||||||||||
| TU(s) encoding the TF: |
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| Regulon |
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| Regulated gene(s) | murP, murQ, murR | ||||||
| Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
carbon compounds (1)
Phosphotransferase Systems (PEP-dependent PTS) (1)
murein turnover, recycling (1)
Transcription related (1)
transcriptional level (1)
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| Regulated operon(s) | murQP-yfeW, murR | ||||||
| First gene in the operon(s) | murQ, murR | ||||||
| Simple and complex regulons | CRP,MurR MurR | ||||||
| Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) | ||||||
| Transcription factor regulation |
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Transcription factor binding sites (TFBSs) arrangements
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| Evolutionary conservation of regulatory elements | |
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| Promoter-target gene evolutionary conservation |
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| Reference(s) |
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[EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] Binding of purified proteins